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  • A single-strand nick in the parental DNA helix just ahead of a replication fork causes the replication fork to break. Recovery from this calamity requires  <div class='qna-option

A single-strand nick in the parental DNA helix just ahead of a replication fork causes the replication fork to break. Recovery from this calamity requires

 

Option: 1

DNA ligase


Option: 2

Site-specific recombination


Option: 3

DNA primase


Option: 4

Homologous recombination


Answers (1)

best_answer

Recovery from a replication fork break caused by a single-strand nick in the parental DNA helix requires DNA repair mechanisms to repair the damaged DNA and restore the replication fork, following mechanism can be involved in the recovery process:

Homologous recombination: In this process, the broken replication fork can be repaired by using the intact sister chromatid as a template for DNA synthesis and repair. The broken DNA end invades the intact sister chromatid and uses it as a template for DNA synthesis and repair, allowing the replication fork to be reestablished.

Hence, the correct answer is option 4.

Posted by

shivangi.bhatnagar

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