Transport of Carbon Dioxide -
Nearly 20-25 percent of CO2 is transported by RBCs:
- The carbon dioxide that enters the RBCs forms a reversible compound with an amino group (NH2) of the globin part of haemoglobin.
- The compound so formed is called carbaminohemoglobin.
70 percent of it is carried as bicarbonate:
- In the RBCs, a zinc enzyme carbonic anhydrase speeds up the formation of carbonic acid.
- Carbonic acid is a weak acid and quickly dissociates into hydrogen and bicarbonate ions.
- The hydrogen ions are buffered by the haemoglobin to form the haemoglobinic acid.
- As bicarbonate ions accumulate in the RBCs, some of them diffuse out into the plasma to prevent the formation of CO2 in the RBCs.
- In order to maintain the ionic balance of blood plasma, the chloride ions diffuse into the RBCs.
- This phenomenon is called the chloride shift or Hamburger Phenomenon
- The bicarbonate ions in the plasma combine with sodium ions to form sodium bicarbonate. These form an important buffering system.
Carbon dioxide that enters the RBCs forms a reversible compound with amino group
of globin part of hemoglobin. The compound so formed in called carbaminohemoglobin.
View full answer