It is well known that Queen Victoria of England was a carrier for haemophilia. Since this is an X-linked disease, it can be predicated that
All of her sons would have had disease
All her daughters would have been carriers
Her father must definitely have had haemophilia
Haemophilia would have occurred in more of her male than her female descendants
Cause of Haemophilia -
A single protein that is a part of the cascade of a protein involved in the clotting of blood is affected.
- wherein
The heterozygous female (carrier) for haemophilia may transmit the disease to sons.
Eg: The family pedigree of Queen Victoria shows the number of haemophilia decedents and she was the carrier.
Correct option is 4