The Hardy-Weinberg principle cannot operate if
a population does not migrate for a longtime to a new habitat
frequent mutations occur in the population
the population has no chance of interaction with other populations
free interbreeding occurs among all members of the population.
As we learnt ,
Hardy-Weinberg Equilibrium -
The relative frequencies of various kinds of genes in a large and randomly rating sexual panmictic population tend to remain constant from generation to generation in the absence of mutation, selection and gene flow.
- wherein
Also known as genetic equilibrium or Hardy-Weinberg Principle