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Which of the following activates JG cells to release renin
Option: 1
Increase in glomerular filtration rate
Option: 2
Passage of urea into the medullary interstitium
Option: 3
Atrial natriuretic factor
Option: 4
Fall in glomerular filtration rate
Answers (1)
Regulation of Kidney Function -
- The functioning of the kidneys is efficiently monitored and regulated by hormonal feedback mechanisms involving the hypothalamus, JGA and to a certain extent, the heart.
Control by Juxtaglomerular Apparatus:
- The JGA plays a complex regulatory role.
- A fall in glomerular blood flow/glomerular blood pressure/GFR can activate the JG cells to release renin which converts angiotensinogen in the blood to angiotensin I and further to angiotensin II.
- Angiotensin II, being a powerful vasoconstrictor, increases the glomerular blood pressure and thereby GFR.
- Angiotensin II also activates the adrenal cortex to release Aldosterone.
- Aldosterone causes reabsorption of Na+ and water from the distal parts of the tubule.
- This also leads to an increase in blood pressure and GFR.
- This complex mechanism is generally known as the Renin-Angiotensin-Aldosterone mechanism.
-
A fall in glomerular blood flow/glomerular blood pressure/ can activate the
cells to release renin which converts angiotensinogen in blood to angiotensin
and further to angiotensin
. Hence the correct option is d. fall in glomerular filteration rate
View full answer
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