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  • How do enzymes catalyze a chemical reaction in the living system? Explain drug target interaction taking the example of an enzyme as a target.

How do enzymes catalyze a chemical reaction in the living system? Explain drug target interaction taking the example of an enzyme as target.

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Enzymes play the main role in biochemical reactions as they are the catalysts, their types of mechanisms of catalyzes are -

(i) The active site of the enzyme captures the substrate and holds it in a particular position so as to react effectively with the substrate. Some of the types of forces involved in binding of the substrate with the active site include ionic bonding, hydrogen bonding, van der Waals, and dipole-dipole, interactions.

(ii) Enzymes also work as a catalysts by providing functional groups to attack the substrate in order to complete the chemical reactions. This role is acted out by amino acid residues of protein found on the enzyme’s active site. They attack the substrate to carry out chemical reactions. The enzyme inhibitor drugs hinder this process by blocking the active site attachment of the substrate.

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Gurleen Kaur

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