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  • Explain the life cycle of Plasmodium in man.

Explain the life cycle of Plasmodium in man.

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  • Plasmodium enters the human body as sporozoites (infectious form) through the bite of infected female Anopheles mosquito. 
  • The parasites initially multiply within the liver cells and then attack the red blood cells (RBCs) resulting in their rupture. 
  • The rupture of RBCs is associated with the release of a toxic substance, hemozoin, which is responsible for the chill and high fever recurring every three to four days.
  • When a female Anopheles mosquito bites an infected person, these parasites enter the mosquito’s body and undergo further development. 
  • The parasites multiply within them to form sporozoites that are stored in their salivary glands. When these mosquitoes bite a human, the sporozoites are introduced into his/ her body, thereby initiating the events mentioned above. 
  • It is interesting to note that the malarial parasite requires two hosts – humans and mosquitoes – to complete its life cycle.
  • The female Anopheles mosquito is the vector (transmitting agent) too.
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Ritika Jonwal

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