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Please explain Erythroblastosis Fetalis

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  • During pregnancy, Rh incompatibility is seen when the father’s blood is Rh+ while the mother’s blood is Rh-. 
  • Therefore, if a father’s blood is Rh+ and the mother’s blood is Rh-, the blood of their baby will be Rh+ ( Rh+ is dominant over Rh- ). 
  • In such interaction, generally, the first child does not suffer, however, the subsequent foetuses do
  • In the subsequent foetuses, anti-Rh factors of mothers blood attack and destroy the RBCs of the foetus. This leads to haemolytic disease of the newborn or HDN
  • This condition is called erythroblastosis fetalis.
  • The newborns that survive are anaemic 
  • Therefore, Marriage between Rh- woman and Rh+ man is not recommended.
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Ritika Jonwal

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