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  • Protein found in a biological system with a unique three-dimensional structure, and biological activity is called a native protein.

Protein found in a biological system with a unique three-dimensional structure, and biological activity is called a native protein. When a protein in its native form, is subjected to a physical change like change in temperature or a chemical change like change in pH, denaturation of protein takes place. Explain the cause.

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When the protein is in its native form, it is intact with its secondary and tertiary structures along with primary structure. These amino acid residues are connected via hydrogen bonds and the intermolecular forces. But when it is subjected to changes like temperature and pH, these structures get destroyed except the primary structure due to the disturbance in the hydrogen bonds. This process unfolds the native protein and is called denaturation of proteins

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