Sickle cell anemia is: 

  • Option 1)

    caused by substitution of valine by glutamic acid in the beta globin chain of haemoglobin

  • Option 2)

    caused by a change in a single base pair of DNA

  • Option 3)

    characterized by elongated sickle like RBCs with a nucles

  • Option 4)

    an autosomal linked dominant trait

 

Answers (1)
V Vakul

As learnt

Cause of Sickle-cell anaemia -

It is caused by the substitution of glutamic acid (Glu) by Valine (Val) at the 6th position of beta globin chain of the haemoglobin molecule.

 

- wherein

The mutant haemoglobic molecule undergoes polymerisation under low oxygen tension causing the change in shape of RBC from bioconcave disc to elongated sickle line structure.

 

 Sicke cell anaemia is caused by substitution of glutanic acid by valine.


Option 1)

caused by substitution of valine by glutamic acid in the beta globin chain of haemoglobin

This option is incorrect

Option 2)

caused by a change in a single base pair of DNA

This option is correct

Option 3)

characterized by elongated sickle like RBCs with a nucles

This option is incorrect

Option 4)

an autosomal linked dominant trait

This option is incorrect

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