If both parents are carriers for thalessemia, which is an autosomal recessive disorder, what are chances of pregnancy resulting in an affected child?
As we discussed in
Mendelian disorders -
These disorders are mainly determined by alteration or mutation in a single gene. Most common Mendelian disorders are Haemophilia, cystic fibrosis, Sickle cell, anaemia.
The Mendelian disorders may be dominant or recessive.
Thalassemia is the disorder due to reduced synthesis of either the alpha or beta chains, likewise designated as alpha or beta - thalassemias. When this autosomal mutant gene is present in a double dose. The disease is severely called as thalassemia major.