Under which of the following conditions will there be no change in the reading frame of following mRNA?

5'AAGAGCGGUGCUAUU3'

Option 1) Insertion of G at 5th position

Option 2) Deletion of G from 5th position

Option 3) Inseration of  A and G at 4th  and 5th position respectively

Option 4) Deletion of GGU from 7th ,8th  and 9th positions

Answers (1)

Insertion or deletion of one or two bases changes the reading frame from the position of insertion or deletion. Hence, option 1,2 and 3 would cause change in reading frme. Deletion of three bases delets a codon and reading frame remains unaltered from that point onwards.

Deletion of GGU from 7th ,8th  and 9th positions, No change in reading frame of m-RNA.

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