Spindles are arrested by colchicine at which stage of mitosis?

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Colchicine, Mitosis, and Karyotypes. The alkaloid drug, colchicine, extracted from the corm of the autumn crocus (Colchicum autumnale), arrests mitosis in metaphase by interfering with the formation of spindle fibrils, thereby retarding the division of the centromeres and preventing division of the centrioles.

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