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  • Explain the process of making heterogenous nuclear RNA (hnRNA) into a fully functional mRNA n eukaryotes. Where does this process occur in the cell?       <div style=

Explain the process of making heterogenous nuclear RNA (hnRNA) into a fully functional mRNA n eukaryotes. Where does this process occur in the cell?

 

 

 

 
 
 
 
 

Answers (1)

The process of making hnRNA into a functional mRNA occurs in the nucleus of a eukaryotic cell. Process of conversion of hnRNA into mRNA -

Heterogeneous nuclear RNA(hnRNA) is the precursor of mRNA and is transcribed by RNA polymerase II

The primary transcripts contain both the exons and the introns and are non-functional. Hence, it is subjected to a process called splicing where the introns are removed and exons are joined in a defined order. hnRNA undergoes two additional processing called as capping and tailing. In capping an unusual nucleotide (methyl guanosine triphosphate) is added to the 5'-end of hnRNA.

In tailing, adenylate residues (200-300) are added at 3'-end in a template-independent manner. The fully processed hnRNA, now called mRNA, is transported out of the nucleus for translation.

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Priyanka Kumari

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