Nuclear fusion and fission can be explained on the basis of-
Binding energy per nucleon variation with nucleon number
Variation of mass with increasing atomic nucleus
Conversion of energy principle
Einstein mass-energy equivalence relation
We have already discussed that both Nuclear Fission and Fusion are processes in which mass is converted into energy.
Hence, nuclear fission and fusion can be explained on the basis of Einstein mass-energy equivalence relation.
Out of the given four options (4) seems to be the most appropriate one.
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