As we have studied in:
Dosage Compensation, Barr Body & Lyon Hypothesis -
- In man, it has been found that Y-chromosomes are genetically inert in comparison to the X-chromosomes and other chromosomes and only a few genes are present in the human Y-chromosome.
- As per the chromosomal make-up of human male and female, females contain a higher dose of a functional gene containing chromosome than males (Female chromosome numbers = 44 + XX and Male chromosome number = 44 + XY).
- The mechanism of compensating the differential doses of functional sex chromosomes in male and female human is affected by the inactivation of one X-chromosome in the normal female.
- The genetically inactive X- chromosome or condensed X-chromosome is called heterochromatin or sex-chromatin body or Barr body.
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Dosage compensation through inactivation of one of the X-chromosomes is seen in females (XX) of mammals.
Hence, the correct answer is option a.
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