Excision repair systems replace a short stretch of DNA around the site of damage. The following statements are made about nucleotide excision repair in E. coli:
A. UvrB homodimer creates the nicks on one strand on both sides of the lesion.
B. The 50-60 residue-long stretch of DNA between the two nicks is removed by the action of UvrD.
C. The gap generated is filled in typically by DNA polymerase I.
D. The distortion caused by the lesion is recognized and bound by the UvrA and UrB complex.
Which one of the following options represents the combination of all correct statements?
A and B only
A, B and D
C and D
B, C and D
Exonuclease enzyme nicks the damaged strands of both sides of the lesion and removes the damaged area.Hence, the correct answer is option 3.