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- #National Eligilibility Cum Entrance Test
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Exposing an organism to a certain chemical can change nucleotide bases in a gene, causing mutation. In one such mutated organism if a protein had only 70% of the primary amino acid sequence, which of the following is likely?
Mutation broke the protein.
The organism could not make amino acids.
Mutation created a terminator codon.
The gene was not transcribed.
Answers (1)
If a protein has only 70% of the primary amino acid sequence and a termination codon was created, it suggests the occurrence of a nonsense mutation. A nonsense mutation introduces a premature stop codon in the gene sequence, resulting in the termination of protein synthesis before the full amino acid sequence is translated.
In this case, the mutation caused the protein synthesis machinery to encounter a premature stop codon, signaling the end of translation. As a result, the protein is truncated and lacks the remaining amino acids that would have been encoded by the mutated gene.
The presence of a termination codon prematurely halts protein synthesis and often leads to the production of a non-functional or significantly impaired protein. The truncated protein may lack essential functional domains or structural elements, affecting its ability to perform its normal physiological role.
Hence, the correct answer is option 3.
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