How does DNA replication terminate in eukaryotes?
The replication fork collapses
The DNA polymerase reaches the end of the chromosome
The DNA polymerase encounters a termination signal
None of the above.
DNA replication in eukaryotes is bidirectional and initiates at multiple origins of replication. Once the two replication forks meet, DNA replication terminates. The termination signal is recognized by specific proteins, which then lead to the disassembly of the replication machinery. Thus, option 3 is the correct answer.