How does dosage compensation occur in Drosophila?
By inactivating one X chromosome in females
By activating one X chromosome in males
By duplicating the X chromosome in males
By deleting one X chromosome in females
Dosage compensation in Drosophila occurs by inactivating one of the two X chromosomes in females. This ensures that the same amount of gene products are produced from X-linked genes in both males (which only have one X chromosome) and females (which have two X chromosomes). In Drosophila, this is achieved through the expression of the X-linked gene, Xist (X-inactive specific transcript), which is responsible for the transcriptional silencing of one of the X chromosomes in females. This process is called X-inactivation or X-chromosome dosage compensation. In males, the single X chromosome is fully expressed without the need for dosage compensation.
Option 1 is the correct answer.