How does the major groove of A-DNA differ from that of B-DNA?
The major groove becomes wider and flattened in A-DNA.
The major groove becomes narrower and more profound in A-DNA.
The major groove remains the same in both A-DNA and B-DNA.
None of the above.
In A-DNA, the major groove becomes narrower and more profound, whereas the minor groove becomes wider and flattened. This is a distinguishing characteristic of A-DNA compared to B-DNA. Hence, option 2 is the correct answer.