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How were the different forms of DNA discovered?
Through electron microscopy analysis of DNA crystals
Through X-ray diffraction analysis of DNA crystals at atomic resolution
Through NMR spectroscopy of DNA molecules in solution
Through genetic sequencing of different organisms
Answers (1)
The different forms of DNA, such as A-DNA, B-DNA, and Z-DNA, were discovered through X-ray diffraction analysis of DNA crystals at atomic resolution. This technique involves directing X-rays at a crystal of the DNA molecule and analyzing the pattern of X-ray diffraction produced by the atoms in the crystal. This allows researchers to determine the 3D structure of the molecule and identify the different forms of DNA that exist. Electron microscopy can be used to visualize DNA molecules, but it does not provide the atomic-level resolution needed to identify the different forms of DNA. NMR spectroscopy can provide information about the chemical properties of DNA in solution, but it is not a high-resolution imaging technique. Genetic sequencing is used to determine the sequence of DNA nucleotides in a molecule, but it does not provide information about the 3D structure or different forms of DNA. Hence, option 2 is the correct answer.
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