Which statement is wrong for Krebs' cycle?

  • Option 1)

    There are three points in the cycle where NAD+ is reduced to NADH+H+

  • Option 2)

    There is one point in the cycle where FAD+ is reduced to FADH2

  • Option 3)

    During conversion of succinyl CoA to succinic acid, a molecule of GTP is synthesised

  • Option 4)

    The cycle starts with condensation of acetyl group (acetyl CoA) with pyruvic acid to yield citric acid

 

Answers (1)

As discussed in

Kreb's cycle TCA / Citric Acid Cycle -

It operates in the mitochondria matrix. All enzymes of Kreb's cycle is present in matrix but succinate dehydrogenase is present on inner mitochondrial membrane.

2 Acetyl CoA + 6H2O + 6NAD+ + 2FAD + 2GDP + 2Pi \rightarrow 4Co2 + 2H2O + 6NADH + 6H+ + 2FADH2 + 2GTP + 2 Coenzyme A

- wherein

 

 Kreb's cycle starts with the synthesis of citrate by addition of water molecule (hydration).


Option 1)

There are three points in the cycle where NAD+ is reduced to NADH+H+

This option is incorrect.

Option 2)

There is one point in the cycle where FAD+ is reduced to FADH2

This option is incorrect.

Option 3)

During conversion of succinyl CoA to succinic acid, a molecule of GTP is synthesised

This option is incorrect.

Option 4)

The cycle starts with condensation of acetyl group (acetyl CoA) with pyruvic acid to yield citric acid

This option is correct.

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