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In the context of treating ADA deficiency, which option correctly identifies a reason why introducing the gene isolated from marrow cells into early embryonic cells could potentially result in a permanent cure, amidst the following perplexing choices?
Early embryonic cells exhibit a higher degree of differentiation compared to later-stage cells.
Early embryonic cells undergo continuous cell multiplication without differentiation.
Early embryonic cells are more amenable to manipulation compared to later-stage cells.
Early embryonic cells possess virtually immortal characteristics.
Answers (1)
Early embryonic cells have the ability to undergo extensive cell division and self-renewal, giving rise to all cell types in the body. They have a high proliferative capacity and can continue dividing for an extended period without undergoing terminal differentiation. This characteristic of immortality makes them a desirable target for gene therapy, as they can potentially propagate and transmit the introduced gene to a large number of cells during embryonic development, leading to a permanent correction of the ADA deficiency. Hence, the correct answer is option 4.
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