# Among the given compounds, the most susceptible to nucleophilic attack at the carbonyl group is: Option 1) $CH_{3}COOCH_{3}$ Option 2) $CH_{3}CONH_{2}$ Option 3) $CH_{3}COOCOCH_{3}$ Option 4) $CH_{3}COCl$

P Plabita

As we learnt in

Nucleophile -

Those e- rich  chemical species having capacity to attack e-deficient portion of substrate.

- wherein

Nucleophile must have complete octet and atleast one lone pair

Lesser the electron density of acyl carbon atom, more is the susceptibility of a nucleophile attack.

The Cl atom has strong -I effect and weakest + R effect. Because of the weak $\pi$ bond between the small size C-atom and the large size Cl atom . Thus in CH3COCl, acyl  carbon has least electron denisty and hence more susceptible for nucleophilic attack.

Option 1)

$CH_{3}COOCH_{3}$

Incorrect

Option 2)

$CH_{3}CONH_{2}$

Incorrect

Option 3)

$CH_{3}COOCOCH_{3}$

Incorrect

Option 4)

$CH_{3}COCl$

Correct

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