Thalassemia and sickle cell anemia are caused due to a problem in globin molecule synthesis. Select the correct statement.

  • Option 1)

    Both are due to a qualitative defect in globin chain synthesis.

  • Option 2)

    Both are due to a quantitative defect in globin chain synthesis.

  • Option 3)

    Thalassemia is due to less synthesis of globin molecules.

  • Option 4)

    Sickle cell anemia is due to a quantitative problem of globin molecules.

 

Answers (1)

As we discussed in concept

Cause of Sickle-cell anaemia -

It is caused by the substitution of glutamic acid (Glu) by Valine (Val) at the 6th position of beta globin chain of the haemoglobin molecule.

 

- wherein

The mutant haemoglobic molecule undergoes polymerisation under low oxygen tension causing the change in shape of RBC from bioconcave disc to elongated sickle line structure.

 

 


Option 1)

Both are due to a qualitative defect in globin chain synthesis.

This option is incorrect.

Option 2)

Both are due to a quantitative defect in globin chain synthesis.

This option is incorrect.

Option 3)

Thalassemia is due to less synthesis of globin molecules.

This option is correct.

Option 4)

Sickle cell anemia is due to a quantitative problem of globin molecules.

This option is incorrect.

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