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Regulation of mRNA translation is a major mechanism that maintains stoichiometric availability of ribosomal proteins (r-proteins) to rRNA molecules they bind to. Translational regulation is facilitated by general occurrence of the r-protein genes in several operons containing multiple genes. Which one of the following represents an established mechanism to ensure optimal production of the r-proteins in E. coli, when the r-proteins accumulate in free form (molar excess over rRNA).

Option: 1

The free r-protein(s) often bind to corresponding DNA sequences and activate transcription of rRNA genes to increase RNA availability.


Option: 2

The free r-protein(s) bind to RNA polymerase and represses transcription of the r-protein genes to decrease the availability of their mRNAs.


Option: 3

The free r-protein(s) bind to the mRNA(s) and downregulate their translation.

 


Option: 4

The free r-protein(s) bind free NTPs which then activate their cryptic ribonuclease activity leading to the degradation of their mRNAs.


Answers (1)

best_answer

Regulation of mRNA translation can be important as an additional layer of control on top of gene transcription, in which RNA binding proteins (RBPs) can modify translation of a set of transcripts to the cell’s actual protein requirement. 

Therefore statement 3 is correct.Hence, the correct answer is option 2. 

 

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