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The base analog 2-aminopurine pairs with thymine, and can occasionally pair with cytosine. The type of mutation induced by 2-aminopurine is
transversion
transition
deletion
nonsense
Answers (1)
The base analog 2-aminopurine can pair with thymine (T) and occasionally pair with cytosine (C). The type of mutation induced by 2-aminopurine is a transition mutation.
A transition mutation is a type of point mutation where one nucleotide is substituted with another nucleotide of the same type. In the case of 2-aminopurine, it can pair with thymine (T) instead of adenine (A) and also pair with cytosine (C) instead of guanine (G).
For example, during DNA replication, if 2-aminopurine is incorporated in place of adenine (A), it can lead to a base substitution where thymine (T) is paired with 2-aminopurine instead of adenine. This substitution of one purine base (A) with another purine base (2-aminopurine) is considered a transition mutation.
Transition mutations involve a change in a pyrimidine-purine base pair to another pyrimidine-purine base pair or a change in a purine-pyrimidine base pair to another purine-pyrimidine base pair. In the case of 2-aminopurine, its ability to pair with both thymine and cytosine can lead to transition mutations in DNA.
Hence, the correct answer is option 2.
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