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What are Okazaki fragments in DNA replication in prokaryotes?

Option: 1

Fragments of DNA synthesized in the leading strand


Option: 2

Fragments of DNA synthesized in the lagging strand


Option: 3

Sites where DNA synthesis is initiated


Option: 4

 None of the above.


Answers (1)

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Okazaki fragments are short, newly synthesized DNA fragments formed during DNA replication in the lagging strand of prokaryotic and eukaryotic DNA. As the replication fork unwinds the double-stranded DNA, the lagging strand is synthesized discontinuously, resulting in the formation of small Okazaki fragments that are later joined together by DNA ligase. Okazaki fragments were named after the Japanese biochemist Reiji Okazaki, who first proposed their existence in 1968. The discovery of Okazaki fragments provided critical evidence for the semi-conservative model of DNA replication, which states that each daughter DNA molecule consists of one parental strand and one newly synthesized strand. Okazaki fragments refer to the fragments of DNA synthesized in the lagging strand. Hence, option 2 is the correct answer.

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Ramraj Saini

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