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Which of the following is not a mechanism of action of antidepressants?
Inhibition of monoamine oxidase (MAO)
Blockade of serotonin and norepinephrine reuptake
Enhancement of serotonin and norepinephrine release
Blockade of acetylcholine receptors
Answers (1)
Correct Answer: D) Blockade of acetylcholine receptors
D) Antidepressants are medications used to treat major depressive disorder, anxiety disorders, and other psychiatric conditions. They work by altering the levels of neurotransmitters such as serotonin, norepinephrine, and dopamine in the brain.
A) Inhibition of monoamine oxidase (MAO): Monoamine oxidase is an enzyme that breaks down neurotransmitters such as serotonin, norepinephrine, and dopamine. MAO inhibitors (MAOIs) are a type of antidepressant that block the action of this enzyme, resulting in increased levels of these neurotransmitters in the brain.
B) Blockade of serotonin and norepinephrine reuptake: Selective serotonin reuptake inhibitors (SSRIs) and serotonin-norepinephrine reuptake inhibitors (SNRIs) are antidepressants that block the reuptake of serotonin and norepinephrine, respectively, into the presynaptic neuron, resulting in increased levels of these neurotransmitters in the synaptic cleft.
C) Enhancement of serotonin and norepinephrine release: Tricyclic antidepressants (TCAs) are a class of antidepressants that increase the release of serotonin and norepinephrine from the presynaptic neuron.
D) Blockade of acetylcholine receptors: Antidepressants do not typically block acetylcholine receptors. However, anticholinergic medications, which do block acetylcholine receptors, are sometimes used to treat depression in older adults, although this is not a first-line treatment due to the potential side effects.
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