Which one of the following cannot be used for preparation of vaccines against plague?
Formalin-inactivated suspensions of virulent bacteria
Avirulent live bacteria
Synthetic capsular polysaccharide material
Heat-killed suspensions of virulent bacteria
Plague is an infectious disease caused by the bacterium Yersinia pestis. Inactivated bacteria have been used since 1890 but have been less effective against pneumonic plague, so live attenuated and recombinant protein vaccines have recently been developed to prevent the disease.Synthetic capsular polysaccharide vaccine for the treatment of pneumonia and meningitis.Therefore, synthetic capsular polysaccharide materials cannot be used in the preparation of vaccines against harmful organisms.
Therefore, the correct answer is "synthetic capsular polysaccharide material". Hence, option 3 is correct.