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Which one of the following statements on nucleic acids is not true?
The conformation of ribose in DNA is alpha-2’-deoxy-D-ribofuranose.
Hydrolysis of RNA takes place under alkaline conditions unlike DNA, as the 2'-hydroxyl in RNA acts as a nucleophile in an intramolecular displacement.
DNA can occur in different three-dimensional forms.
In DNA, deamination of cytosine to uracil can occur in a non-enzymatic manner.
Answers (1)
The statement "The conformation of ribose in DNA is alpha-2’-deoxy-D-ribofuranose" is not true.
In DNA, the sugar component is actually 2'-deoxyribose, not ribose. The presence of a hydrogen atom in place of the hydroxyl group at the 2' position distinguishes deoxyribose from ribose.
The correct statement would be: "The conformation of 2'-deoxyribose in DNA is alpha-2’-deoxy-D-ribofuranose."
It is important to note that the conformation of nucleic acids, including the sugar moiety, plays a significant role in their structure and function. The specific arrangement of the sugar-phosphate backbone and the base pairing interactions contribute to the stability and shape of DNA and RNA molecules. Hence, the correct answer is option 1.
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