Which type of mutation involves the addition or deletion of nucleotides in a DNA sequence?
Silent mutation
Frameshift mutation
Point mutation
Substitution mutation
Frameshift mutations are the kind of changes that occur when nucleotides are added to or subtracted from a DNA sequence. The "reading frame" of the genetic code is shifted as a result, and the entire downstream amino acid sequence in the final protein is altered.
As they take place in the third position of a codon and have no impact on the meaning of the codon, silent mutations are the kind of mutations that do not alter the amino acid sequence of the resulting protein.
Option 2 is the correct answer.