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Q8.    Briefly mention the mechanism of action of FSH.

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Follicle-stimulating hormone (FSH) is a glycoprotein polypeptide hormone. It is insoluble in lipids and hence cannot enter the target cell. This hormone binds to the cell surface and activates cellular systems to perform functions.

Steps in the action of FSH:

  • FSH is secreted by the pituitary gland upon the regulation of the gonadotropin-releasing hormone that acts on the surface of the target cell.
  • A molecule of FSH binds to the receptor protein present on the ovarian cell surface and forms the hormone-receptor complex.
  • The formation of a hormone-receptor complex activates the enzyme adenyl cyclase.
  • Adenylyl cyclase converts ATP into cyclic AMP (cAMP) as a second messenger.
  • cAMP activates the follicular cells of membrane granulose to secrete estrogens.
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Priyanka Kumari

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