An amphibolic pathway refers to a pathway in which both catabolic and anabolic reactions take place. The products of some reactions are used to synthesise other products. Carbohydrates are broken down to glucose before entering respiratory pathways. Fats get converted into fatty acids and glycerol whereas fatty acids get converted into acetyl CoA before entering the respiration. In a similar manner, proteins are converted into amino acids, which enter respiration after deamination. During the synthesis of fatty acids, acetyl CoA is withdrawn from the respiratory pathway. Also, in the synthesis of proteins, respiratory substrates get withdrawn. Thus, respiration involves both anabolism and catabolism in anabolism. Therefore, respiration can be termed as an amphibolic pathway as it involves both anabolism and catabolism.