Among the following layers of the epidermis in humans, which layer primarily functions as the main barrier against water loss and the invasion of disease-causing organisms?
Stratum lucidum
Stratum spinosum
Stratum germinativum
Stratum corneum
Stratum corneum is the outermost layer of the epidermis in humans. It is composed of several layers of flattened, dead skin cells called corneocytes. These cells are rich in keratin, a protein that provides strength and waterproofing properties to the skin. The stratum corneum acts as a protective barrier against water loss, preventing excessive evaporation and maintaining hydration of the body. It also serves as a physical barrier, preventing the entry of disease-causing organisms, pollutants, and harmful substances into the body. The thick and densely packed nature of the cells in the stratum corneum contributes to its protective function, making it the main defense against water loss and external pathogens.
Hence, the correct answer is option 4.