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Assertion: The formation of urea is an essential step in the Krebs-Henseleit cycle.
Reason: The Krebs-Henseleit cycle is a metabolic pathway in the liver that converts toxic ammonia into non-toxic urea, which can be safely excreted from the body.
Assertion and reason are both true, and reason is an accurate account of assertion.
Both assertion and reason are accurate, but reason does not adequately explain assertion.
The assertion is correct, but the reasoning is incorrect.
Both the assertion and reason are incorrect.
Answers (1)
The Krebs-Henseleit cycle, also known as the urea cycle or the ornithine cycle, is a series of biochemical reactions that occur in the liver and some other organs of the body. The primary function of this cycle is to convert toxic ammonia, which is produced during the breakdown of proteins and nucleic acids, into non-toxic urea, which can be excreted in the urine. The formation of urea is, therefore, an essential step in this process.
The assertion is true because without the formation of urea, the Krebs-Henseleit cycle cannot be completed, and toxic ammonia will accumulate in the body, leading to a condition called hyperammonemia. Hyperammonemia can cause a range of symptoms, including neurological problems, lethargy, vomiting, and in severe cases, coma and death.
The reason is also true because the primary purpose of the Krebs-Henseleit cycle is to convert toxic ammonia into non-toxic urea, which can be excreted from the body. The cycle involves five enzymatic reactions, which occur in the mitochondria and cytosol of liver cells. These reactions convert ammonia into urea, using several intermediate compounds, including ornithine, citrulline, and arginine.
In summary, the formation of urea is an essential step in the Krebs-Henseleit cycle, which is a metabolic pathway in the liver that converts toxic ammonia into non-toxic urea. The assertion and the reason are both true, and they support each other to explain the importance of the urea cycle in maintaining ammonia homeostasis in the body.
Option 1 is the correct answer.
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