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At which of the following stages, decarboxylation of citric acid takes place?
 

Option: 1

Isocitrate to α-ketoglutarate


Option: 2

α-ketoglutarate to succinyl CoA


Option: 3

Succinate to fumarate 

 


Option: 4

Both a and b


Answers (1)

best_answer

The decarboxylation of citric acid occurs at two stages in the citric acid cycle (also known as the Krebs cycle or TCA cycle):

  • Isocitrate to α-ketoglutarate: During this step, isocitrate undergoes oxidative decarboxylation, resulting in the formation of α-ketoglutarate. One molecule of carbon dioxide (CO2) is released in this process.
  • α-ketoglutarate to succinyl CoA: In the next step, α-ketoglutarate undergoes another oxidative decarboxylation, leading to the formation of succinyl CoA. Another molecule of carbon dioxide (CO2) is released in this process.

Therefore, the correct answer is Option 4) Both a and b, as both the conversion of isocitrate to α-ketoglutarate and α-ketoglutarate to succinyl CoA involves the decarboxylation of citric acid and the release of carbon dioxide.

 

Posted by

manish painkra

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