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If a person is unable to secrete adequate amounts of serotonin, somatostatin and histamine, which cells of gastric glands are most likely to be dysfunctional?
Option: 1
Chief cells
Option: 2
Zymogenic cell or peptic cell
Option: 3
G-cells
Option: 4
Argentaffin cells
Answers (1)
- The cells of the gastric glands are as follows:
- The cells at the base of these pits are chief cells or zymogenic cell or peptic cell that are responsible for the production of pepsinogen, an inactive precursor of pepsin, which degrades proteins.
- Further up the pits, parietal cells or oxyntic cells produce gastric acid and a vital substance, intrinsic factor. The gastric acid kills most of the bacteria in food, stimulates hunger, and activates pepsinogen into pepsin. It denatures the complex protein molecule as a precursor to protein digestion through enzyme action in the stomach and small intestines.
- Near the top of the pits, closest to the contents of the stomach, there are mucus-producing cells called goblet cells that help protect the stomach from self-digestion.
- The G-cells or entero-enteric cells secrete gastrin hormone.
- The argentaffin cells secrete serotonin, somatostatin and histamine.
The argentaffin cells secrete serotonin, somatostatin and histamine. Thus, if a person is unable to secrete adequate amounts of serotonin, somatostatin and histamine, it means argentaffin cells are dysfunctional. Hence, the correct answer is option d.
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