Juxtaglomerular Apparatus -
- It is located just adjacent to the vascular pole of the renal corpuscle.
- The DCT comes in direct contact of the afferent and efferent arteriole and that region of the DCT forms the macula densa.
- Macula densa is a cluster of cuboidal epithelial cells that monitors the composition of the fluid that flows through the DCT.
- They respond to the concentration of Na+ in the fluid and release the paracrine signals in the form of ATP and adenosine.
- A second cell type in this apparatus is the juxtaglomerular cell.
- This is a modified, smooth muscle cell lining the afferent arteriole that can contract or relax in response to ATP or adenosine released by the macula densa.
- A second function of the macula densa cells is to regulate renin release from the juxtaglomerular cells of the afferent arteriole.
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Juxtaglomerular apparatus is formed by juxtaglomerular cells and macula densa. However, third type of cells called lacis cells are also found in JGA. Hence, the correct option is d. all of the above
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