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The Lyon hypothesis and Barr bodies are most relevant to which aspect of genetics?

Option: 1

Genetic disorders caused by Y chromosome abnormalities


Option: 2

Genetic disorders caused by mutations in autosomal genes


Option: 3

Genetic disorders caused by mutations in X-linked genes


Option: 4

Genetic disorders caused by mitochondrial DNA mutations

 


Answers (1)

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The Lyon hypothesis and Barr bodies are most relevant to the regulation of X-linked gene expression in females. In female cells, one of the two X chromosomes is randomly inactivated during early embryonic development, leading to the formation of a Barr body. This process ensures that the dosage of X-linked genes is equalized between males and females. However, this inactivation can influence the severity and manifestation of genetic disorders caused by mutations in X-linked genes. In these cases, the presence of a Barr body can indicate which X chromosome is inactivated and, therefore, which X-linked gene is affected. This information can be useful in diagnosing and treating X-linked genetic disorders in females.

Option 3  is the correct answer. 

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rishi.raj

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