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What is the mechanism by which neurotransmitters are removed from the synaptic cleft?

Option: 1

Reuptake by the presynaptic neuron

Option: 2

Diffusion into the extracellular fluid

Option: 3

Uptake by glial cells


Option: 4

Breakdown by enzymes in the synaptic cleft

Answers (1)


After neurotransmitters have been released into the synaptic cleft, they are removed from the cleft by a process called reuptake. The presynaptic neuron has transporter proteins on its membrane that bind to and transport the neurotransmitter back into the neuron. Once inside the neuron, the neurotransmitter can be repackaged into vesicles and used again in another transmission event.

Option 1 is the correct answer. 

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