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  • Explain sliding filament theory of muscle contraction with neat sketches

Explain sliding filament theory of muscle contraction with neat sketches.

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As per Sliding filament theory, when actin and myosin filaments slide towards each other, muscle contraction takes place.

  • A neural signal reaching to neuromuscular junction releases a neurotransmitter (Acetylcholine) which generates an action potential in the sarcolemma. Once the action potential is generated, calcium channels in the muscle cells open and allow the entry of calcium ions.
  • An increase of Ca ++ levels results in the binding of calcium to troponin on the actin filament and brings about conformational changes. This removes the masking of active sites on myosin filaments.
  • Myosin a polymer of meromyosins has a head, arm, and tail as its important parts. The head also called heavy meromyosin (HMM) utilizes the energy from ATP hydrolysis and binds with the active site on actin.
  • This results in the formation of a ccross-bridgebetween actin and myosin. This pulls the attached actin filaments towards the centre of the 'A' band. The Z- line attached to actin is also pulled inwards and contraction of muscle fibre happens.

 

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