Control and Regulation of the Cell Cycle
- The regulation of the cell cycle is important so that faulty or compromised cell could not divide.
- There can be a mutation during DNA replication and other events of the cell cycle.
- Therefore, there are checkpoints in the cell cycle that would check for the errors and would stop the cell cycle if there is any fault and would allow the cell cycle to continue if there is no fault.
- There are three checkpoints in the cell cycle as G1 checkpoint, G2 checkpoint and M checkpoint.
G1 checkpoint:
- The G1 checkpoint determines whether all conditions are favourable for cell division to proceed.
- If this checkpoint is crossed, then the cell is irreversibly committed for the cell division.
- This checkpoint checks for adequate reserves, cell size and genomic DNA damage.
- A cell that does not meet all the requirements will not be allowed to progress into the S phase.
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G1 checkpoint checks for adequate reserves, cell size and genomic DNA damage. A cell that does not meet all the requirements will not be allowed to progress into the S phase.
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