If a geneticist uses the blind approach for sequencing the whole genome of an organism, followed by assignment of function to different segments, the methodology adopted by him is called as:
Gene mapping
Expressed sequence tags
Bioinformatics
Sequence annotation
Sequencing the whole set of genomes that contained all the coding and non-coding sequences and later assigning different regions in the sequence with functions is called sequence annotation.
The second approach is EST (Expressed Sequence Tags) in which the focus is on identifying all the genes that are expressed as RNA.
Hence, the correct option is (4).