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Scientists aim to investigate brain tissue samples obtained from individuals who passed away with Alzheimer's disease (AD). To compare these samples with normal brains, they employ autoradiography as a testing method. The findings reveal a notable decrease in the number of receptors for a specific neurotransmitter in diseased brains.
How does autoradiography enable the detection of the reduced receptor count in AD brains?
It quantifies the number of DNA sequences corresponding to the receptors.
It employs a fluorescent dye to label the receptors.
It utilizes a radioactive probe to identify and visualize the receptors.
It s used for counting the DNA copy numbers.
Answers (1)
Autoradiography uses a radioactive probe that binds to specific receptors in brain tissue samples. The emitted radiation from the bound probe is detected, allowing visualization and quantification of the receptors. In Alzheimer's disease (AD) brains, autoradiography reveals a decrease in the number of receptors for a specific neurotransmitter compared to normal brains. This information helps us understand the changes that occur in the brain during Alzheimer’s.Hence, the correct answer is option 3.
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