The allele I in Drosophila is recessive, sex-linked and lethal when homozygous or hemizygous. If a female of the genotype LI is crossed with a male, what is the ratio of females: males in the progeny?
3: 1
2: 1
1: 1
1: 2
In the given cross, where a female of the genotype LI (heterozygous for the lethal allele) is crossed with a male, the ratio of females to males in the progeny is expected to be 2:1.
Let's break down the possible genotypes of the offspring:
Female offspring:
L (normal allele) from the father and I (lethal allele) from the mother: LI (carrier of the lethal allele)
L (normal allele) from both parents: LL (normal, non-carrier)
Male offspring:
L (normal allele) from the father and no allele from the mother: L (normal, non-carrier)
Hence, the correct answer is option 2.