Urine Formation: Glomerular Filtration or Ultrafiltration -
- Kidneys filter 1100-1200 ml of blood per minute.
- The blood pressure in the capillaries of the glomerulus is higher than that of the afferent arteriole due to their narrow lumen.
- This increased blood pressure results in the filtration of the blood across the semipermeable capillaries called ultrafiltration.
- Water and many dissolved substances are filtered into the lumen of the Bowman’s capsule.
- Blood cells and proteins are kept within the bloodstream by the filtration membrane.
- The filtered components in the lumen of the Bowman’s capsule are collectively called the glomerular filtrate.
- It consists of a large amount of water, urea, uric acid, creatinine, amino acids, glucose, sodium, potassium, vitamins, etc.
- If blood pressure increases, the stretch receptors on the afferent arteriole send an impulse to the smooth muscle cells.
- These smooth muscle cells will contract and the diameter of the afferent arteriole is reduced, which in turn restricts the flow of blood.
- The restricted flow of blood to the glomerulus reduces the rate of glomerular filtration.
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The blood pressure in the capillaries of the glomerulus is higher than that of the afferent arteriole due to their narrow lumen.
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