Which of the following analgesics is contraindicated in patients with a history of liver disease?
Acetaminophen
Morphine
Tramadol
Methadone
Acetaminophen is metabolized in the liver, and its metabolites can be toxic to the liver if the
2) Morphine - Morphine is metabolized by the liver, but it does not have a significant risk of liver toxicity, and it can be used in patients with mild to moderate liver disease with caution.
3) Tramadol - Tramadol is metabolized in the liver, and its active metabolite has a longer half-life in patients with liver disease. However, it can be used in patients with mild to moderate liver disease with caution.
4) Methadone - Methadone is metabolized by the liver, and it can accumulate in patients with liver disease. However, it can still be used in patients with mild to moderate liver disease with caution.