Which of the following analgesics works by inhibiting prostaglandin synthesis?
Acetaminophen
Aspirin
Codeine
Fentanyl
Aspirin works by inhibiting cyclooxygenase (COX) enzymes, which are responsible for the synthesis of prostaglandins. Prostaglandins play a key role in inflammation and pain perception. By inhibiting their synthesis, aspirin reduces pain and inflammation.
Incorrect options:
1) Acetaminophen - Acetaminophen works mainly in the brain, where it inhibits the production of prostaglandins, but it does not have a significant effect on peripheral tissues.
3) Codeine - Codeine works by binding to opioid receptors in the brain and spinal cord and does not have a direct effect on prostaglandin synthesis.
4) Fentanyl - Fentanyl is a potent opioid analgesic that works by binding to opioid receptors in the brain and spinal cord, and does not have a direct effect on prostaglandin synthesis.